Role of inducible nitric oxide synthase in trinitrobenzene sulphonic acid induced colitis in mice
نویسندگان
چکیده
منابع مشابه
Amelioration of 2,4,6-trinitrobenzene sulphonic acid induced colitis in angiotensinogen gene knockout mice.
BACKGROUND A number of recent studies have demonstrated a protective effect of renin-angiotensin system (RAS) antagonism against immune mediated diseases such as myocarditis, chronic allograft rejection, and antiglomerular basement membrane nephritis. To our knowledge, there has been no report on the immunological contribution of the RAS in colonic tissue. AIMS We evaluated the direct effect ...
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Crohn's disease (CD) and ulcerative colitis (UC) have different immunological mechanisms, while both of them are potential targets of vitamin D treatment. In this study, we have tried to address the role of vitamin D in CD and UC using two mouse models. Mice of C57B6L were given vitamin D before the induction of colitis. Our results showed that vitamin D attenuated 2,4,6-trinitrobenzene sulphon...
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ژورنال
عنوان ژورنال: Gut
سال: 1999
ISSN: 0017-5749
DOI: 10.1136/gut.45.6.864